Vectra 3D, FirstShield Trio and SimpleGuard 3 Info for Rabbits.

Vectra 3D, FirstShield Trio, and SimpleGuard 3 Information for Rabbits [Updated on: 10/25/18 03:56]

Vectra 3D, FirstShield Trio, & SimpleGuard 3 can cause serious issues with rabbits and *MUST* be used under the direct guidance from a very rabbit savvy vet!!! As with any medication you must first talk to a very rabbit savvy vet for the correct dosage for your rabbit and current situation. The information below is for reference only! The calculator will only show the dosing based on the data inputted. Talk to a very rabbit savvy vet before using Vectra 3D!

Vectra 3D is manufactured by Ceva Animal Health, LLC. Ceva writes that it will repel and kill fleas, ticks, mosquitoes, lice (biting & Sucking), mites (excluding mange mites), and biting & sand flies on dogs. There is no 'official use' for rabbits currently and it's considered an "off label" or extralabel use for a rabbit.

SimpleGuard 3 is manufactured by Summit VetPharm, LLC for Vethical, a part of VCA (Veterinary Centers of America), the largest chain of animal hospitals in the US and Canada (700+). FirstShield Trio is manufactured for Banfield Pet Hospitals. There are over 860+ Banfield Pet Hospitals across the U.S., including the ~800 located inside most PetSmarts. Both products have the same active ingredients as Vectra 3D.

NOTE: These products will not prevent Myxomatosis!! They try to protect the rabbit by killing or repelling some of the vectors that can bite the rabbit that transmit the deadly virus. Biosecurity is a must in these areas! These pages are here for reference only.

Vectra 3D box Colors & Sizes

Active ingredients - Vectra 3D, FirstShield Trio, and SimpleGuard 3.

Neonicotinoid Dinotefuran: Kills fleas quickly
Pyriproxyfen: Photo stable insect growth inhibitor, halts development of larva, pupa, and egg
The pyrethroid Permethrin: Repels and kills ticks, black flies, deer flies, mosquitoes and cheyletiella mites... does not repel or kill demodex or sarcoptes as they burrow too fast
Note: Normally a product with any of these chemicals should be avoided with rabbits, but with an extreme case like Myxomatosis (no vaccine in the USA) this might be an option you can talk to your rabbit savvy vet about.

Permethrin is the key ingredient that does the repelling. It can be useful by repelling some of the insects that spread the myxomatosis virus, but it can cause chemical burns! If not dosed and applied correctly the rabbit can get chemical burns! See a rabbit savvy vet!

Dosing - There is no real protocol for dosing rabbits currently with Vectra 3D.

Department of Animal Parasitology, Veterinary Institute, Federal Rural University of Rio de Janeiro

This 2018 study was done on 12 Adult New Zealand rabbits (treated: n=6, control no treatment: n=6) testing the efficacy with cat fleas. Calculated ingredient dosage range using the study's numbers:

Dosing range 0.125 — 0.166 mL/kg
Dinotefuran	6.19	—	8.25	mg/kg
Pyriproxyfen	0.55	—	0.73	mg/kg
Permethrin	45.10	—	60.13	mg/kg

The study notes: "further studies are necessary to evaluate the safety of this formula in rabbits that undergo a superior number of repeated applications."

Adobe Pet Hospital & B.U.N.S. - Bunnies Urgently Needing Shelter

The Bunnies Urgently Needing Shelter (BUNS) rescue has the Myxomatosis virus in their area and have been using Vectra 3D for 2 years without issues. BUNS uses a dosing protocol used by Dr. Haskell & Dr. Gibbs at Adobe Pet Hospital (Santa Barbara, Ca.). They use the Vectra 3D 0.8 mL pipette from the Yellow/Gold box. Dr. Haskell & Dr. Gibbs dosing levels are just a bit higher than what the study used, but theirs are for different uses. Here is a overlap chart.

Please read their very informative page on Myxomatosis and use of Vectra 3D by Jean Silva. Please read the biosecurity section on their webpage... as it's a must in these types of areas!

Under 5 lbs 0.4 mL (1/2 pipette)
Over 5 lbs 0.8 mL (1 pipette)
See a rabbit savvy before using!
Comparison chart on how the dosing BUNS (Adobe Pet Hospital) uses and the Brazilian university mesh up

Vectra 3D	Box Color			Liquid	Medicine amount per pipette			Dog & Puppy
Box	Vectra 3D	SimpleGuard 3	FirstShield Trio	Amount	Dinotefuran	Pyriproxyfen	Permethrin	Weight (on box)
	Yellow (Gold)	Blue	Note: FirstShield Trio Teal box is 2.5 - 20 lbs ↓	0.8 mL	A: 39.6 mg EU: 43.2 mg	A: 3.52 mg EU: 3.872 mg	A: 288.64 mg EU: 317.6 mg	Extra Small - XS 5 - 10 lbs 1.5 - 4.0 kg
	Teal	Green	Teal	1.6 mL	A: 79.2 mg EU: 86.4 mg	A: 7.04 mg EU: 7.744 mg	A: 577.28 mg EU: 635.2 mg	Small - S 11 - 20 lbs 4.0 - 10.0 kg FirstShield Trio: 2.5 - 20 lbs
	Blue	Gold (Yellow)	Blue	2.6 mL	A: 178.2 mg EU: 194.4 mg	A: 15.84 mg EU: 17.424 mg	A: 1298.88 mg EU: 1429.2 mg	Medium - M 21 - 55 lbs 10.0 - 25.0 kg
	Purple	Red	Purple	4.7 mL	A: 232.65 mg EU: 253.8 mg	A: 20.68 mg EU: 22.748 mg	A: 1695.76 mg EU: 1865.9 mg	Large - L 56 - 95 lbs 25.0 - 40.0 kg
	Red	Purple	Red	8.0 mL	A: 396 mg EU: 432 mg	A: 35.2 mg EU: 38.72 mg	A: 2886.4 mg EU: 3176 mg	Extra Large - XL Over 95 lbs Over 40.0 kg

NOTE: Vectra 3D can have regional concentration differences... A = Americas, EU = Euro.

How should Vectra 3D, FirstShield Trio, & SimpleGuard 3 be stored?

"Store in a cool, dry place. Protect from freezing. Do not contaminate water, food or feed by storage and disposal."
Disposal: "If empty, do not reuse the container. Place in trash or offer for recycling if available. If partially filled, call your local solid waste agency for disposal instructions. Never place unused products down any indoor or outdoor drain."

Manufacture & Information Sheets:

Vectra 3D MSDS Rev 4 (August 20, 2012) - PDF
Vectra 3D Box Information Sheet (Teal box) Sep 2013 - PDF
US EPA, Vectra 3D Pesticide Product Label (SVP7) 02/07/2014 - PDF
EU 10-25 kg Box Directions - JPG

Studies:

2018; "Efficacy of a dinotefuran, pyriproxyfen and permethrin combination product against Ctenocephalides felis felis (Bouché, 1835) (Siphonaptera: Pulicidae) on artificially infested rabbits."
Borges DA, de Abreu Moraes P, Cardoso JD, de Oliveira PC, Yasui AM, Paulino Fernandes IM, Lambert MM, Correa TR, Scott FB, Veterinary Parasitology (2018), 2018 Aug 15;259:74-79. doi: 10.1016/j.vetpar.2018.07.006. Epub 2018 Jul 17. [Abstract;]

Other Information:

If you look on Ceva Animal Health's FAQs web page you will find:

A direct email response from Ceva Animal Health on inquiring on the safety of Vectra 3D and rabbits:

"We currently do not have any studies with using the Vectra 3D on rabbits and it would be considered off-label use at the discretion of the veterinarian. Please consult with your veterinarian for further direction" - July, 2017.

How do you say: Dinotefuran , Pyriproxyfen, and Permethrin.