Rabbit Revolution, Paradyne, Stronghold, Selehold, & Clearkill SMT [Selamectin] Information Rabbits [Updated on: 07/14/23 10:59]

As with any medication you must first talk to a rabbit savvy vet for the correct dosage for your rabbit and current situation. The information below is for reference only! The calculator will only show the dosing based on the data inputted. Talk to a rabbit savvy vet! Note: Zoetis now sells a few new product called Revolution Plus & Stronghold Plus. These new versions should not be used on rabbits as there are no efficacy, safety, pharmacokinetics, or adverse studies conducted on rabbits yet.         Selamectin is sold under the brand names of Revolution, Paradyne, Stronghold, Selehold, Xelamec, and Clearkill SMT. It's used to treat and eliminate some parasites (fleas & mites) on a rabbit. It works by "causing neuromuscular paralysis, impaired muscular contraction, and eventual death", in the parasite. When used correctly it works very well with rabbits. There is no 'offical use' for rabbits currently and it's considered an "off label" use, but rabbit savvy vets will use it when it's safe for a rabbit, like any other medication.         Revolution and Stronghold are made by Zoetis Inc. Depending on what country you are in you could have access to both brands. In many countries you may need to see a vet first for a prescription and correct dosing.         Paradyne is manufactured by the same company (Zoetis Inc.) that makes Revolution. It's made for Vethical, a part of VCA (Veterinary Centers of America), the largest chain of animal hospitals in the US and Canada (700+). It's identical to Revolution.         Clearkill SMT is manufactured by DCI (Disinfecto Chemical Industries Pvt. Ltd.) and is made for the pet market in India and surrounding countries. NOTE!! DCI also makes many products called Clearkill "Spot ON" that is extremely dangerous to rabbits!! Clearkill "Spot ON" uses fipronil. Clearkill SMT is the correct product. If this is confusing do not use it and see a rabbit savvy vet!! Calculate individual dosing (based on data inputted) with calculator below. Pipette dosing comparison chart when using 1 pink, blue, or taupe pipette. Configurable general dosing chart that is printable. Box Colors & Concentrations.

       In most countries Revolution is considered an extralabel (or off-label) use for rabbits. The graphic below is from the offical Revolution webpage in Australia. In Australia Revolution is registered (by Zoetis) to treat ear mites, sarcoptic mange, and cheyletiellosis in rabbits from as early as 8 weeks of age.

"Unlike other products, Revolution is not classified as a Scheduled Poison."

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Efficacy and Safety of Selamectin (Stronghold® /Revolution™) Used Off-Label in Exotic Pets From: The Journal of Applied Research in Veterinary Medicine • Vol. 5, No. 3, 2007, page 88 By: Maggie Fisher, DVM, DiplEVPC Wieland Beck, DVM, DiplEVPC Melanie J. Hutchinson, DVM - [pdf] Dr.H at the HRS International HQ recomends 0.05 mL per 1 pound using the concentration of 120 mg/kg. This works out to 12.228 mg/kg, this is used the calculator below.

See chart above (best given by rabbit-savvy vet).

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To use the calculator below you will need a few bits of information.

1. Target dosage in mg/kg. Many rabbit-savvy will dose between 12-15 mg/kg. Best given by a rabbit-savvy vet.
2. Rabbit's weight in pounds (lb) or kilograms (kg).
3. Concentration. This info can be found on the package or by looking at the chart below. This will be 60 mg/mL or 120 mg/mL.
4. Double check your entries and press "Calculate ↵"

Calculate for mL dosage Target dosage in mg/kg: mg/kg Rabbit's weight kg lbs   Concentration in mg/mL: mg/mL Dosage in mL: ≈ 0.2 mL Enter values & click calculate 1 cc or cc³ (cubic centimeter) = 1 ml or mL (milliliter) "≈" = "almost equal to"

Based on the numbers entered, your rabbit of 1kg (2.2lbs) would use a dose of 0.2ml (0.2cc), of Revolution. You are using the concentration of 60mg/ml, therefore your rabbit is getting a dosage of 12.23mg of medicine per 1kg of body weight (12.23mg/kg). Math for a 1kg or 2.2lb rabbit: 12.23mg/kg × 1kg ÷ 60mg/ml ≈ 0.2ml 12.228mg/kg × 1kg = 12.228mg || 12.228mg ÷ 60mg/ml = 0.2038ml ≈ 0.2ml (0.2cc) If you are writing down any information please read: "Unsafe Medical Abbreviations"

Revolution Paradyne Stronghold Selehold Xelamec Clearkill SMT Concentration Liquid amount Medicine amount Dog/Cat Weight on Box Box Color (Click on Box) Mauve Rose Pink Blue 60 mg/ml 0.25 ml 15 mg/tube Kitten/Puppy up to 5 lbs ≤ 2.5 kg Rose 60 mg/ml 0.5 ml 30 mg/tube Dog/Cat 5.5 to 11 lbs 2.5 to 5.0 kg Blue Teal Blue Turquoise 60 mg/ml 0.75 ml 45 mg/tube 5.1 to 15 lbs 2.6 to 7.5 kg Taupe Taupe Taupe Taupe Taupe 60 mg/ml 1.0 ml 60 mg/tube 15.1 to 22 lbs 7.6 to 10.0 kg Box Color (Click on Box) Purple Blue (Aqua) Violet Violet 120 mg/ml 0.25 ml 30 mg/tube 5.1 to 10 lbs 2.6 to 5.0 kg Brown Green (Lime) Brown Orange 120 mg/ml 0.5 ml 60 mg/tube 10.1 to 20 lbs 5.1 to 10.0 kg Red Gold (Orange) Red Red Blue 120 mg/ml 1.0 ml 120 mg/tube 20.1 to 40 lbs 10.1 to 20.0 kg Teal Red Green (Teal) Green Green 120 mg/ml 2.0 ml 240 mg/tube 40.1 to 85 lbs 20.1 to 40.0 kg Plum Purple Plum Blue 120 mg/ml 3.0 ml 360 mg/tube 85.1 to 130 lbs 40.1 to 60 kg Chart © 2015-2023 http://www.vgr1.com/revolution

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How should Revolution be stored?

• "Revolution flea control is flammable. Never use it near open flames (including cigarettes), sparks or other sources of heat/flame that could result in ignition. Revolution flea control should be stored at room temp (below 30C), in a cool, dry place. The product should not be exposed to high temperatures or sources of flames or ignition. Should a fire occur - you need to use dry chemical, foam, or carbon dioxide to put it out. Do not put water on a fire involving Revolution flea control as it is similar to an oil fire." - Dr. O'Meara
• "Revolution is flammable – Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal." - Zoetis PDF

Manufacture Information Sheets:

• Revolution Client Information sheet Feb 2014 - PDF
• Revolution prescribing information sheet Feb 2014 - PDF
• Revolution safety data sheet v5.3 - PDF
• Revolution MSDS v2.0.0 - PDF
• Revolution Freedom of Information Summary FDA June/13/2000 - PDF
• Stronghold (EU) Summary Of Product Characteristics - PDF
• Paradyne Product Insert (Vethical) PAA034348 - PDF

Studies:

• 2012; "Pharmacokinetics, efficacy, and adverse effects of selamectin following topical administration in flea-infested rabbits"
  James W. Carpenter, MS, DVM; Michael W. Dryden, DVM, PhD; Butch KuKanich, DVM, PhD. American Journal of Veterinary Research, April 2012, Vol. 73, No. 4, Pages 562-566, doi: 10.2460/ajvr.73.4.562. [Abstract; Press release]
• 2009; "Comparison of selamectin and imidacloprid plus permethrin in eliminating Leporacarus gibbus infestation in laboratory rabbits (Oryctolagus cuniculus)."
  Birke LL, Molina PE, Baker DG, Leonard ST, Marrero LJ, Johnson M, Simkin J., J Am Assoc Lab Anim Sci. 2009 Nov;48(6):757-62., PMID: 19930824 [Abstract; Article]
• 2008; "Treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study."
  Marianne Mellgren and Kerstin Bergvall, Acta Vet Scand. 2008; 50(1): 1, Published online 2008 Jan 2. doi: 10.1186/1751-0147-50-1 [Study;]
• 2008; "Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits."
  Kim SH, Lee JY, Jun HK, Song KH, Park BK, Kim DH., Vet Dermatol. 2008 Feb;19(1):26-7. doi: 10.1111/j.1365-3164.2007.00629.x. [Abstract;]
• 2008; "A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats"
  Maggie A Fisher and David J Shanks, Acta Vet Scand. 2008; 50(1): 46, doi: 10.1186/1751-0147-50-46. [Paper;]
• 2007; "Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits."
  Kurtdede A1, Karaer Z, Acar A, Guzel M, Cingi CC, Ural K, Ica A., Vet Dermatol. 2007 Feb;18(1):18-22., PMID: 17222235 [Abstract;]
• 2003; "Efficacy and safety of topical administration of selamectin for treatment of ear mite infestation in rabbits."
  McTier TL, Hair JA, Walstrom DJ, Thompson L., J Am Vet Med Assoc. 2003 Aug 1;223(3):322-4., PMID: 12906226 [Abstract;]

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Other Resources

Rabbits For Pets had a very good page on Mites & Rabbits but in late 2017 the page went dark.

Below is their dosing chart and video, using the old dose of 6 mg/kg for mites, based on the older 2003 study. The information is here for reference.

   

Revolution Flea Control (active ingredient: Selamectin). Information about revolution for pets by Dr. O'Meara.

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Revolution Plus & Stronghold Plus - Do not use on rabbits - There are no pharmacokinetics, efficacy, safety, or adverse studies studies conducted on rabbits yet.

        The U.S. FDA (Food & Drug Administration) released a fact sheet alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. This includes sarolaner that was added to Revolution Plus & Stronghold Plus. - FDA source. Do Not Use On Rabbits!!

• U.S. Food and Drug Administration update: Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products

        In late 2018 Zoties released Revolution Plus & Stronghold Plus spot-on treatment for cats. Zoetis added sarolaner to the selamectin based product(s). This should not be used on rabbits. There are no pharmacokinetics, efficacy, safety, or adverse studies studies conducted on rabbits yet.

        The "Plus" versions adds the S-enantiomer of sarolaner. "Sarolaner is an acaricide and insecticide belonging to the isoxazoline family. The primary target of action of sarolaner in insects and acarines is functional blockade of ligand-gated chloride channels (GABA-receptors and glutamate-receptors). Sarolaner blocks GABA- and glutamate-gated chloride channels in the nervous system of insects and acarines. Disruption of these receptors by sarolaner prevents the uptake of chloride ions by GABA and glutamate ion channels, thus resulting in increased nerve stimulation and death of the target parasite. Sarolaner exhibits higher functional potency to block insect/acarine receptors compared to mammalian receptors."

Problems reported with cats and Revolution Plus [source]:

• One female cat in the 3.75X group was found dead on study day 115. The cause was determined to be hemorrhage in multiple tissues secondary to a low platelet count.
• During an exploratory margin of safety study, one cat in the 60 mg/kg/ 10 mg/kg (selamectin/sarolaner) group (5X dose group) experienced piloerection, tremors, and mydriasis approximately 24 hours after receiving the third monthly dose of the combination.
• Oral administration of the highest recommended topical dose of REVOLUTION PLUS to kittens resulted in transient lower food consumption and clinical findings of emesis, soft feces, and salivation. In one male, mild tremor was observed and resolved...

Rabbits & Selamectin + Sarolaner The European Medicines Agency (CVMP) assessment reports the following on rabbits:

• Ocular irritation: moderately irritating
• Dermal irritation: non-irritating

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